Expertise in "OMICS Technologies"
Over the last 15 years, "OMIC Technology" has grown along with the Life Sciences Industry and Modern Medicines. As part of a sub-set of synergy between Biotechnology and "OMICS Technology", Liquid Chromatography Mass Spectrometry (LC MS) has become one of the most widely used technologies for such fields as proteomics, metabolomics, histone epigenetics, lipidomics, glycomics, etc. As well, LC MS also has strong roots in the Biopharma Industry with regard to biologics characterization of antibodies, fusion proteins, DAR, etc).
One of the End Goals of "OMICS Technology" is to bring together multi-dimensional data that will help describe results on the Progression of Illness Treatment with a Prescribed Precision Medicine Treatment.
This would be useful for understanding outcomes based on the prescribed medicine.
OMICS Technology is used to describe the molecular phenotype of an organism.
Each OMICS technology is a different discipline (proteomics, metabolomics) and has different experimental methods and nuances.
Below, you will find useful information and definitions related to the
sub-fields of "OMICS Technologies"
Protein Network Mapping or Proteomics for Disease Research and Drug Interactions
"Network" or "MOA" Proteomics
The study of Protein Flux during different states in cells, tissue, etc. - rater it be the difference between normal and disease state and/or differences in cell cycles. Proteins can be further broken down by function and each functional class has similar structures. From there, different pathways for biosynthesis can be rendered.
There are Several Valuable Resources already written in Regards to the definition and Success of "Pathway Proteomics" or "Mechanism-of-Action Proteomics".
Please see this website for a more in-depth description proteomics:
The Key to Clinical Research and
"Background Wellness Assays"
Clinical Research and Biomarker Discovery
Metabolomics is becoming a workhorse technology for Clinical Research Type Projects
Results from Clinical Research can often be translated over to a more targeted, Clinical Diagnostics platform.
Type I - Global Metabolomics
Type II - Targeted Metabolomics
Type III - Hypothesis driven Metabolomics (i.e. Fluxomics with Heavy labeled tracer molecules)
This is a broad topic that describes the overall flux of Small Molecules in the body. The metabolome is dictated by genetics, protein flux, and environment (food, water, etc.).
Targeted metabolomics allows for mapping of specific “bio-synthetic” pathways (Note: Small Molecule is to indicate “NOT a Protein”.)
Please see these websites for a more in-depth description:
Rapid analysis of Histone Epigenetic Marks
A Targeted Proteomics Experiment
Epigenetics – This field has two major research streams: DNA and Chromatin Epigenetics. We focus on the Histone protein(s) Epigenetic Mark Identification and Quantification.
Brief Explination: Depending on the “molecular switches” that are turned on, or off at the molecular level, the DNA can be 'exposed' or 'closed' to the transcription of RNA.
The interest here is to measure the "molecular switches" that control the Chromatin/DNA structure.
Please see this website for a more in-depth description – Histone Specific Epigenetics:
Beta Version 2020 Version
Beta Version 2020 Version